Gregory is an illustrator specializing in natural science subjects. His first illustrated science book, a book about dinosaurs for G.P. Putnam Sons, was done in 1982. Since then Gregory has worked on many projects for clients ranging from book and magazine publishers to natural history museums to television. Some of his jobs have called on him to provide science art for The Tonight Show, paintings to be used as posters for Newbridge Communications, or illustrations for Michael Crichton's The Lost World.